Addition of nucleotides between position +11 and +30 on HIV-1 transcript (R-HSA-167115) [Homo sapiens]


RNA polymerase II transcription complexes are susceptible to transcriptional stalling and arrest, when extending nascent transcripts to 30-nt. This susceptibility depends on presence on down-stream DNA, the particular DNA-sequence of the template and presence of transcription factors. Transcription factor TFIIH remains associated to the RNA pol II elongation complex until position +30. At this stage transcription elongation factor TFIIS can rescue stalled transcription elongation complexes. The transcription bubble varies between 13- and 22-nt in size.

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Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
RNA Polymerase II (unphosphorylated):TFIIF complex DNA-directed RNA polymerase activity (0003899)
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
11433015 Analysis of the open region of RNA polymerase II transcription complexes in the early phase of elongation. Nucleic Acids Res 2001
11486021 Promoter clearance by RNA polymerase II is an extended, multistep process strongly affected by sequence. Mol Cell Biol 2001
9353262 Promoter escape by RNA polymerase II. Formation of an escape-competent transcriptional intermediate is a prerequisite for exit of polymerase from the promoter. J Biol Chem 1997
7601352 Recycling of the general transcription factors during RNA polymerase II transcription. Genes Dev 1995
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Inferred From