Reactome: A Curated Pathway Database

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (R-HSA-167153) [Homo sapiens]

Reaction
Summation

The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript.

Additional Information
Compartment nucleoplasm
Diseases
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
24354960 Cap-binding complex (CBC) Biochem. J. 2014