Reactome: A Curated Pathway Database

HIV Transcription Elongation (R-HSA-167169) [Homo sapiens]

Pathway
Summation

In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below.

Additional Information
Compartment nucleoplasm
GO Biological Process transcription elongation from RNA polymerase II promoter (0006368)
Diseases
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
15049426 Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages Curr HIV Res 2003
10550206 Tackling Tat J Mol Biol 1999