Reactome: A Curated Pathway Database

HIV Transcription Elongation (R-HSA-167169)

Species Homo sapiens

Summation

In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process transcription elongation from RNA polymerase II promoter (0006368)
Diseases
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
15049426 Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages Curr HIV Res 2003
10550206 Tackling Tat J Mol Biol 1999