Reactome: A Curated Pathway Database
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HIV Transcription Elongation

Stable Identifier
R-HSA-167169
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below.

Literature References
PubMed ID Title Journal Year
15049426 Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages Curr HIV Res 2003
10550206 Tackling Tat J Mol Biol 1999
Participants
Participant Of
Inferred From
Disease
Diseases
Name Identifier Synonyms