Reactome: A Curated Pathway Database

Formation of HIV-1 elongation complex containing HIV-1 Tat (R-HSA-167200) [Homo sapiens]


This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).

Additional Information
Compartment nucleoplasm
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]