Reactome: A Curated Pathway Database

HIV elongation arrest and recovery

Stable Identifier
R-HSA-167287
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
Summation

RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. TFIIS reactivates arrested RNA Pol II by promoting the excision of nascent transcript ~7-14 nucleotides upstream of the 3' end.

Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms