Reactome: A Curated Pathway Database

Phosphorylated MAPKs phosphorylate ATF-2

Stable Identifier
R-HSA-168053
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'ATF-2' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'ATF-2-P' are present.

This reaction is mediated by the 'protein kinase activity' of 'MAPK1-P'.

the Raf√Ę‚?¨‚??MEK√Ę‚?¨‚??ERK pathway induces phosphorylation of ATF2 Thr71, whereas subsequent ATF2 Thr69 phosphorylation requires the Ral√Ę‚?¨‚??RalGDS√Ę‚?¨‚??Src√Ę‚?¨‚??p38 pathway. Cooperation between ERK and p38 was found to be essential for ATF2 activation by these mitogens; the activity of p38 and JNK/SAPK in growth factor-stimulated fibroblasts is insufficient to phosphorylate ATF2 Thr71 or Thr69 + 71 significantly by themselves, while ERK cannot dual phosphorylate ATF2 Thr69 + 71 efficiently.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events