Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells.
|GO Biological Process||toll-like receptor 10 signaling pathway (0034166)|
|15728506||Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88||J Immunol||2005|
|18332149||The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer||J Biol Chem||2008|