Reactome: A Curated Pathway Database

Phosphorylation of human JNKs by activated MKK4/MKK7 (R-HSA-168162)

Species Homo sapiens

Summation

Activated human JNK kinases (MKK4 and MKK7) phosphorylate Thr183 and Tyr185 residues in the characteristic Thr-Pro-Tyr phosphoacceptor loop of each JNK.

JNK is differentially regulated by MKK4 and MKK7 depending on the stimulus. MKK7 is the primary activator of JNK in TNF, LPS, and PGN responses. However, TLR3 cascade requires both MKK4 and MKK7. Some studies reported that in three JNK isoforms tested MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183).

Locations in the PathwayBrowser
Cellular responses to stress(Homo sapiens)
Immune System(Homo sapiens)
Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-MAP2K4/p-MAP2K7 JUN kinase kinase activity (0008545)