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Phosphorylation of human JNKs by activated MKK4/MKK7

Stable Identifier
R-HSA-168162
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated human JNK kinases (MKK4 and MKK7) phosphorylate Thr183 and Tyr185 residues in the characteristic Thr-Pro-Tyr phosphoacceptor loop of each JNK.

JNK is differentially regulated by MKK4 and MKK7 depending on the stimulus. MKK7 is the primary activator of JNK in TNF, LPS, and PGN responses. However, TLR3 cascade requires both MKK4 and MKK7. Some studies reported that in three JNK isoforms tested MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
Physical Entity
Activity
Orthologous Events