Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections.
Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.
|GO Biological Process||toll-like receptor 3 signaling pathway (0034138)|
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|15733829||Transcriptional signaling by double-stranded RNA: role of TLR3||Cytokine Growth Factor Rev||2005|
|18202435||Sensing of viral infection and activation of innate immunity by toll-like receptor 3||Clin Microbiol Rev||2008|