Reactome: A Curated Pathway Database

Toll Like Receptor 3 (TLR3) Cascade (R-HSA-168164) [Homo sapiens]


Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections.

Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.

Additional Information
GO Biological Process toll-like receptor 3 signaling pathway (0034138)
Cross References
Database Identifier
BioModels Database BIOMD0000000477