Reactome: A Curated Pathway Database

Toll Like Receptor TLR1:TLR2 Cascade (R-HSA-168179) [Homo sapiens]


TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

Additional Information
GO Biological Process toll-like receptor TLR1:TLR2 signaling pathway (0038123)
Cross References
Database Identifier
BioModels Database BIOMD0000000477
Literature References
pubMedId Title Journal Year
12975352 Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling J Cell Biol 2003