Reactome: A Curated Pathway Database

Toll Like Receptor 7/8 (TLR7/8) Cascade

Stable Identifier
R-HSA-168181
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus-1 (HIV-1), for example, stimulate dendritic cells (DC) and macrophages to secrete interferon-alpha and proinflammatory, as well as regulatory, cytokines. This has been found to be mediated by TLR7, as well as TLR8. Separate studies showed that imidazoquinoline compounds (e.g. imiquimod and R-848, low-molecular-weight immune response modifiers that can induce the synthesis of interferon-alpha) also exert their effects in a MyD88-dependent fashion independently through TLR7 and 8 (Heil et al. 2004).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database