Reactome: A Curated Pathway Database

Toll Like Receptor TLR6:TLR2 Cascade

Stable Identifier
R-HSA-168188
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

TLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recognizing peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides. In particular, TLR6 appears to participate in discriminating the subtle differences between dipalmitoyl and tripalmitoyl cysteinyl residues (Okusawa et al. 2004).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database