Viral Messenger RNA Synthesis

Stable Identifier
R-HSA-168325
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
Summation

Like the mRNAs of the host cell, influenza virus mRNAs are capped and polyadenylated (reviewed in Neumann, 2004). The methylated caps, however, are scavenged from host cell mRNAs and serve as primers for viral RNA synthesis, a process termed 'cap-snatching' (Krug, 1981; Hagen, 1994). The PB2 polymerase protein binds the cap, activating endonucleolytic cleavage of the host mRNA by PB1. The 3' poly-A tracts on viral messages are generated by polymerase stuttering on poly-U tracts near the 5' end of the template vRNA (Robertson, 1981; Zheng, 1999). The second process allows polyadenylation of viral mRNAs when the host cell polyadenylation process has been inhibited (Engelhardt, 2006; Amorim, 2006). Notably, early transcripts (including NP and NS1) accumulate in the cytoplasm before late transcripts (M1, HA, and NS2), and in varying abundances, suggesting additional control mechanisms regulating viral gene expression (Shapiro, 1987; Hatada, 1989; Amorim, 2006).

Literature References
PubMed ID Title Journal Year
16806605 Influenza A virus and the cell nucleus

Amorim, MJ, Digard, P

Vaccine 2006
15298169 Orthomyxovirus replication, transcription, and polyadenylation

Neumann, G, Brownlee, GG, Fodor, E, Kawaoka, Y

Curr Top Microbiol Immunol 2004
16933365 Functional association between viral and cellular transcription during influenza virus infection

Engelhardt, OG, Fodor, E

Rev Med Virol 2006
Participants
Participant Of
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed