Reactome: A Curated Pathway Database

Formation of Cyclin B:Cdc2 complexes

Stable Identifier
R-HSA-170057
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site.

Literature References
Participants
Participant Of
Orthologous Events
Cross References