Reactome: A Curated Pathway Database
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Formation of Cyclin B:Cdc2 complexes

Stable Identifier
R-HSA-170057
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site.

Literature References
Participants
Participant Of
Orthologous Events