Reactome: A Curated Pathway Database

Formation of Cyclin B:Cdc2 complexes (R-HSA-170057) [Homo sapiens]


Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site.

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Compartment cytosol
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Literature References
pubMedId Title Journal Year
1717476 Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport J Cell Biol 1991