Reactome: A Curated Pathway Database

Formation of Cyclin B:Cdc2 complexes (R-HSA-170057)

Species Homo sapiens

Summation

Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Cross References
Database Identifier
IntAct IM-23674-13, IM-17935-4, IM-12101-2, IM-11591-4, IM-14935-1, IM-19945-3, EBI-515191
Literature References
pubMedId Title Journal Year
1717476 Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport J Cell Biol 1991