Reactome: A Curated Pathway Database

Formation of Cyclin A:Cdc2 complexes

Stable Identifier
R-HSA-170084
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cyclin A is synthesized and associates with Cdc2 in G1. Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active sites are blocked by a portion of the CDK molecule itself. Binding to their corresponding cyclin partner results in a conformational change that partially exposes the active site.

Literature References
Participants
Participant Of
Orthologous Events