Reactome: A Curated Pathway Database

Formation of Cyclin A:Cdc2 complexes (R-HSA-170084) [Homo sapiens]

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Summation

Cyclin A is synthesized and associates with Cdc2 in G1. Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active sites are blocked by a portion of the CDK molecule itself. Binding to their corresponding cyclin partner results in a conformational change that partially exposes the active site.

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Compartment cytosol
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