Reactome: A Curated Pathway Database

Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes (R-HSA-170145) [Homo sapiens]


Cyclin A:Cdc2 complexes are detected in the nucleus earlier that cyclin B1:Cdc2 complexes and may play a role in the initial events in prophase. Inactivation of Cdc25B by proteasome-mediated degradation is dependent upon cyclin A:Cdc2-mediated phosphorylation (Cans et al, 1999)

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
10363647 Proteasome-dependent degradation of human CDC25B phosphatase Mol Biol Rep 1999