Reactome: A Curated Pathway Database

Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170158
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activation of the mitotic cyclin:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2. This dephosphorylation is achieved by the activity of the Cdc25 family of phosphatases. The Cdc25 members, Cdc25A, Cdc25B, and Cdc25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004)

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoprotein phosphatase activity of CDC25 [nucleoplasm] CDC25 [nucleoplasm] phosphoprotein phosphatase activity (0004721)
Inferred From