Reactome: A Curated Pathway Database

Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (R-HSA-170158) [Homo sapiens]


Activation of the mitotic cyclin:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2. This dephosphorylation is achieved by the activity of the Cdc25 family of phosphatases. The Cdc25 members, Cdc25A, Cdc25B, and Cdc25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004)

Additional Information
Compartment nucleoplasm
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Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
CDC25 phosphoprotein phosphatase activity (0004721)