Reactome: A Curated Pathway Database

Adenylate cyclase inhibitory pathway (R-HSA-170670) [Homo sapiens]


Guanine nucleotide-binding protein G(i) alpha (Gi-alpha) inhibits adenylate cyclase, thus inhibiting the production of cAMP from ATP and ultimately decreasing the activity of cAMP-dependent protein kinase.

Literature References
pubMedId Title Journal Year
14993377 Isoforms of mammalian adenylyl cyclase: multiplicities of signaling Mol Interv 2002