Reactome: A Curated Pathway Database

ARMS-mediated activation (R-HSA-170984) [Homo sapiens]

Pathway
Summation

ARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which is involved in the activation of Rap1 and the subsequent prolonged activation of the MAPK cascade.

Literature References
pubMedId Title Journal Year
9069267 Signal transduction by the neurotrophin receptors Curr Opin Cell Biol 1997