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p38MAPK events
Stable Identifier
R-HSA-171007
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
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NGF induces sustained activation of p38, a member of the MAPK family (Morooka T, Nishida E, 1998). Both p38 and the ERKs appear to be involved in neurite outgrowth and differentiation caused by NGF in PC12 cells. As a matter of fact, PC12 cell differentiation appears to involve activation of both ERK/MAPK and p38. Both ERK/MAPK and p38 pathways contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes (Xing J, 1998). p38 activation by NGF may occur by at least two mechanisms, involving SRC or MEK kinases.
Literature References
PubMed ID
Title
Journal
Year
9297626
Ras effectors and their role in mitogenesis and oncogenesis
Joneson, T
,
Bar-Sagi, D
J Mol Med
1997
Participants
Events
Ral-GDS binds to Ras-GTP
(Homo sapiens)
Guanine nucleotide exchange on RAL
(Homo sapiens)
SRC-1 autophosphorylates
(Homo sapiens)
Binding and activation of MAP Kinase
(Homo sapiens)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
(Homo sapiens)
Participates
as an event of
Signalling to RAS (Homo sapiens)
Orthologous Events
p38MAPK events (Bos taurus)
p38MAPK events (Caenorhabditis elegans)
p38MAPK events (Canis familiaris)
p38MAPK events (Danio rerio)
p38MAPK events (Drosophila melanogaster)
p38MAPK events (Gallus gallus)
p38MAPK events (Mus musculus)
p38MAPK events (Rattus norvegicus)
p38MAPK events (Sus scrofa)
p38MAPK events (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000466
,
BIOMD0000000940
,
BIOMD0000000468
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2006-01-25)
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