Reactome: A Curated Pathway Database

p38MAPK events (R-HSA-171007) [Homo sapiens]


NGF induces sustained activation of p38, a member of the MAPK family (Morooka T, Nishida E, 1998). Both p38 and the ERKs appear to be involved in neurite outgrowth and differentiation caused by NGF in PC12 cells. As a matter of fact, PC12 cell differentiation appears to involve activation of both ERK/MAPK and p38. Both ERK/MAPK and p38 pathways contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes (Xing J, 1998). p38 activation by NGF may occur by at least two mechanisms, involving SRC or MEK kinases.

Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000466
Literature References
pubMedId Title Journal Year
9297626 Ras effectors and their role in mitogenesis and oncogenesis J Mol Med 1997