Reactome: A Curated Pathway Database

p38MAPK events

Stable Identifier
R-HSA-171007
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

NGF induces sustained activation of p38, a member of the MAPK family (Morooka T, Nishida E, 1998). Both p38 and the ERKs appear to be involved in neurite outgrowth and differentiation caused by NGF in PC12 cells. As a matter of fact, PC12 cell differentiation appears to involve activation of both ERK/MAPK and p38. Both ERK/MAPK and p38 pathways contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes (Xing J, 1998). p38 activation by NGF may occur by at least two mechanisms, involving SRC or MEK kinases.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database