Reactome: A Curated Pathway Database

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (R-HSA-173545) [Homo sapiens]

Black Box Event

The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway.

Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Catalyst Activity
PhysicalEntity Activity Active Units
Nuclear ubiquitin ligase ubiquitin-protein transferase activity (0004842)  
Literature References
pubMedId Title Journal Year
10587642 Ubiquitin-dependent degradation of TGF-beta-activated smad2 Nat Cell Biol 1999
10587654 SMAD destruction turns off signalling Nat Cell Biol 1999