Reactome: A Curated Pathway Database

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (R-HSA-173545)

Species Homo sapiens

Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Catalyst Activity
PhysicalEntity Activity Active Units
Nuclear ubiquitin ligase ubiquitin-protein transferase activity (0004842)
Literature References
pubMedId Title Journal Year
10587642 Ubiquitin-dependent degradation of TGF-beta-activated smad2 Nat Cell Biol 1999
10587654 SMAD destruction turns off signalling Nat Cell Biol 1999