There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

Stable Identifier
R-HSA-173545
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway.

Literature References
PubMed ID Title Journal Year
10587642 Ubiquitin-dependent degradation of TGF-beta-activated smad2 Nat Cell Biol 1999
10587654 SMAD destruction turns off signalling Nat Cell Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]
Physical Entity
Activity
Orthologous Events