Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

Stable Identifier
R-HSA-173545
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway.
Literature References
PubMed ID Title Journal Year
10587654 SMAD destruction turns off signalling

ten Dijke, P, Heldin, CH

Nat Cell Biol 1999
10587642 Ubiquitin-dependent degradation of TGF-beta-activated smad2

Massague, J, Lo, RS

Nat Cell Biol 1999
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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