Reactome: A Curated Pathway Database

SCF-beta-TrCP mediated degradation of Emi1

Stable Identifier
R-HSA-174113
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Emi1 destruction in early mitosis requires the SCF beta-TrCP ubiquitin ligase complex. Binding of beta-TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as well as Cdk mediated phosphorylation. A two-step mechanism has been proposed in which the phosphorylation of Emi1 by Cdc2 occurs after the G2-M transition followed soon after by binding of beta-TrCP to the DSGxxS phosphorylation sites. Emi1 is then poly-ubiquitinated and degraded by the 26S proteasome.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database