Reactome: A Curated Pathway Database

Cdc20:Phospho-APC/C mediated degradation of Cyclin A (R-HSA-174184) [Homo sapiens]


Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited.

Cross References
Database Identifier
BioModels Database BIOMD0000000194, BIOMD0000000186, BIOMD0000000193, BIOMD0000000220, BIOMD0000000187, BIOMD0000000293