Reactome: A Curated Pathway Database

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Stable Identifier
R-HSA-174184
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited.

Literature References
Participants
Participant Of
Orthologous Events
Cross References