Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited.
|GO Biological Process||anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (0031145)|
|BioModels Database||BIOMD0000000194, BIOMD0000000186, BIOMD0000000193, BIOMD0000000220, BIOMD0000000187, BIOMD0000000293|
|11285280||Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint||J Cell Biol||2001|