Reactome: A Curated Pathway Database

Processive synthesis on the C-strand of the telomere

Stable Identifier
R-HSA-174414
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once polymerase switching from pol alpha to pol delta is complete the processive synthesis of a short run of DNA called an Okazaki fragment begins. DNA synthesis is discontinuous and as the extending Okazaki fragment reaches the RNA primer, this primer is folded into a single-stranded flap, which is removed by endonucleases. The process of extension is completed by the ligation of adjacent Okazaki fragments.

Literature References
Participants
Participant Of
Orthologous Events