Reactome: A Curated Pathway Database

Telomere C-strand (Lagging Strand) Synthesis (R-HSA-174417)

Species Homo sapiens

Summation

Due to the antiparallel nature of DNA, DNA polymerization is unidirectional, and one strand is synthesized discontinuously. This strand is called the lagging strand. Although the polymerase switching on the lagging strand is very similar to that on the leading strand, the processive synthesis on the two strands proceeds quite differently. Short DNA fragments, about 100 bases long, called Okazaki fragments are synthesized on the RNA-DNA primers first. Strand-displacement synthesis occurs, whereby the primer-containing 5'-terminus of the adjacent Okazaki fragment is folded into a single-stranded flap structure. This flap structure is removed by endonucleases, and the adjacent Okazaki fragments are joined by DNA ligase.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process telomere maintenance via semi-conservative replication (0032201)
Literature References
pubMedId Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004