Reactome: A Curated Pathway Database

Membrane binding and targetting of GAG proteins

Stable Identifier
R-HSA-174490
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

One of the mysteries of Gag protein involvement in HIV virion assembly is how the proteins are targeted to the proper membrane for budding. Infectious retroviruses do not bud from all of the available membrane surfaces within an infected cell, but primarily from the plasma membrane, which constitutes a small proportion of the total membrane surface in most cells. In polarized cells, the sites of budding are further restricted to the basolateral membrane.

Literature References
PubMed ID Title Journal Year
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Participant Of
Disease
Diseases
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Cross References
BioModels Database