Reactome: A Curated Pathway Database

APC/C:Cdc20 mediated degradation of mitotic proteins (R-HSA-176409) [Homo sapiens]


Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005)

Cross References
Database Identifier
BioModels Database BIOMD0000000194, BIOMD0000000186, BIOMD0000000193, BIOMD0000000220, BIOMD0000000187, BIOMD0000000293
Literature References
pubMedId Title Journal Year
15949434 The D box asserts itself Mol Cell 2005
10465783 Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 1999