APC/C:Cdc20 mediated degradation of mitotic proteins

Stable Identifier
R-HSA-176409
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005)

Literature References
PubMed ID Title Journal Year
10465783 Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 1999
15949434 The D box asserts itself Mol Cell 2005
Participants
Participant Of
Orthologous Events