Phosphorylation of the APC/C

Stable Identifier
R-HSA-176412
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation in vivo have not been determined with certainty, both Plk1 and Cyclin B:Cdc2 have been implicated in this process.

Literature References
PubMed ID Title Journal Year
10793135 Mitotic regulation of the APC activator proteins CDC20 and CDH1 Mol Biol Cell 2000
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database