Reactome: A Curated Pathway Database

Phosphorylation of the APC/C (R-HSA-176412) [Homo sapiens]


Phosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation in vivo have not been determined with certainty, both Plk1 and Cyclin B:Cdc2 have been implicated in this process.

Cross References
Database Identifier
BioModels Database BIOMD0000000186, BIOMD0000000187
Literature References
pubMedId Title Journal Year
10793135 Mitotic regulation of the APC activator proteins CDC20 and CDH1 Mol Biol Cell 2000