Reactome: A Curated Pathway Database

Phosphorylation of the APC/C

Stable Identifier
R-HSA-176412
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation in vivo have not been determined with certainty, both Plk1 and Cyclin B:Cdc2 have been implicated in this process.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database