We will be undergoing a brief scheduled maintenance at Monday Jan 22 at 10AM EST - you may experience some outages

We will be undergoing a scheduled maintenance at Monday Jan 22 at 10AM EST

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

APC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein Cdc20. APC/C:Cdc20 promotes the multiubiquitination and ordered degradation of Cyclin A and Nek2 degradation in prometaphase followed by Cyclin B and securin in metaphase (Reviewed in Castro et al., 2005).

Literature References
PubMed ID Title Journal Year
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle Oncogene 2005
Participant Of
Orthologous Events