Reactome: A Curated Pathway Database
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Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Stable Identifier
R-HSA-176814
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

APC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein Cdc20. APC/C:Cdc20 promotes the multiubiquitination and ordered degradation of Cyclin A and Nek2 degradation in prometaphase followed by Cyclin B and securin in metaphase (Reviewed in Castro et al., 2005).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events