Reactome: A Curated Pathway Database

Unwinding of DNA

Stable Identifier
R-HSA-176974
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M phase of the cell cycle. DNA helicase activity of some of the MCM family proteins are important for the unwinding of DNA and initiation of replication processes. This section contains four events which have been proved in different eukaryotic experimental systems to involve various proteins for this essential step during DNA Replication.

Literature References
Participants
Participant Of
Orthologous Events