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Interactions of Rev with host cellular proteins
Stable Identifier
R-HSA-177243
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
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In order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nuclear import appears to be achieved by the association of Rev with importin-beta and B23 and docking at the nuclear pore through interactions between importin-beta and nucleoporins. The dissociation of Rev with the import machinery and the subsequent export of Rev-associated HIV-1 mRNA complex requires Ran-GTP. Ran GTP associates with importin-beta, displacing its cargo. Crm1 associates with the Rev:RNA complex and Ran:GTP and is believed to interact with nucleoporins facilitating docking of the RRE-Rev-CRM1-RanGTP complex to the nuclear pore and the translocation of the complex across the nuclear pore complex. In the cytoplasm, RanBP1 associates with Ran-GTP causing the Crm1-Rev-Ran-GTP complex to disassemble. The Ran GAP protein promotes the hydrolysis of RanGTP to Ran GDP. The activities of Ran GAP in the cytoplasm and Ran-GEF, which converts RAN-GDP to Ran-GTP in the nucleus, produce a gradient of Ran-GTP/GDP required for this shuttling of Rev and other cellular transport proteins.
Literature References
PubMed ID
Title
Journal
Year
9837918
The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP
Jensen, TH
,
Englmeier, L
,
Nilsson, J
,
Askjaer, P
,
Kjems, J
J Biol Chem
1998
Participants
Events
Nuclear import of Rev protein
(Homo sapiens)
Rev-mediated nuclear export of HIV RNA
(Homo sapiens)
Participates
as an event of
Host Interactions of HIV factors (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2005-07-27)
Rice, AP (2005-07-27)
Reviewed
Kumar, A (2007-02-01)
Created
Matthews, L (2006-03-24)
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