Expression of WFS1

Locations in the PathwayBrowser

Metabolism of proteins (Homo sapiens)

• • Unfolded Protein Response (UPR) (Homo sapiens)
    • IRE1alpha activates chaperones (Homo sapiens)
      • XBP1(S) activates chaperone genes (Homo sapiens)
        • Expression of WFS1 (Homo sapiens)

Summation

The WFS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Literature References

PubMed ID	Title	Journal	Year

16539657

XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells

J Neurochem

2006

Participants

input

• WFS1 gene [nucleoplasm] (Homo sapiens)

output

• WFS1 [endoplasmic reticulum membrane] (Homo sapiens)

Participant Of

hasEvent

• XBP1(S) activates chaperone genes

This entity is regulated by:

Positive Regulation

• 'XBP1(S) [nucleoplasm]' positively regulates 'Expression of WFS1'