Reactome | Chondroitin sulfate/dermatan sulfate metabolism

Chondroitin sulfate/dermatan sulfate metabolism

Stable Identifier

R-HSA-1793185

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Chondroitin sulfate/dermatan sulfate metabolism

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Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). The chains are usually attached to proteins forming a proteoglycan. CS is an important structural component of cartilage due to it's ability to withstand compression. It is also a widely used dietary supplement for osteoarthritis. When some of the GlcA residues are epimerized into L-iduronic acid (IdoA) the resulting disaccharide is then referred to as dermatan sulfate (DS) (Silbert & Sugumaran 2002). DS is the most predominant GAG in skin but is also found in blood vessels, heart valves, tendons, and the lungs. It may play roles in cardiovascular disease, tumorigenesis, infection, wound repair and fibrosis (Trowbridge & Gallo 2002).

Literature References

PubMed ID	Title	Journal	Year
17239764	Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches Mourão, PA, Pavão, MS, Vilela-Silva, AC	Adv Pharmacol	2006
12512856	Biosynthesis of chondroitin/dermatan sulfate Sugumaran, G, Silbert, JE	IUBMB Life	2002
12213784	Dermatan sulfate: new functions from an old glycosaminoglycan Trowbridge, JM, Gallo, RL	Glycobiology	2002