GRB2 events in EGFR signaling

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Autophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through its SH2 domain. GRB2 is constitutively associated with SOS, a guanine nucleotide exchange factor of RAS. GRB2 binding to phosphorylated EGFR results in the recruitment of SOS to the plasma membrane where it comes in proximity to RAS. This mechanism has been seen to be the model for RAS activation.

Literature References
PubMed ID Title Journal Year
11498013 Internalization of the epidermal growth factor receptor: role in signalling Biochem Soc Trans 2001
11706405 GRB2: a pivotal protein in signal transduction Semin Oncol 2001
Participant Of
Orthologous Events