Reactome: A Curated Pathway Database

Synthesis of nascent polypeptide containing signal sequence (R-HSA-1799335)

Species Homo sapiens


The synthesis of a protein destined for the endoplasmic reticulum starts with the canonical events of cytosolic translation initiation and proceeds to the point where a nascent polypeptide chain containing a signal sequence protrudes from the mRNA:ribosome complex. Merrick (2010) provides an overview of these events.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
20444697 Eukaryotic protein synthesis: still a mystery J Biol Chem 2010