Reactome: A Curated Pathway Database

Synthesis of nascent polypeptide containing signal sequence

Stable Identifier
R-HSA-1799335
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The synthesis of a protein destined for the endoplasmic reticulum starts with the canonical events of cytosolic translation initiation and proceeds to the point where a nascent polypeptide chain containing a signal sequence protrudes from the mRNA:ribosome complex. Merrick (2010) provides an overview of these events.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events