Reactome: A Curated Pathway Database

SHC1 events in EGFR signaling (R-HSA-180336) [Homo sapiens]


GRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.

Literature References
pubMedId Title Journal Year
11498013 Internalization of the epidermal growth factor receptor: role in signalling Biochem Soc Trans 2001
8755247 Not all Shc's roads lead to Ras Trends Biochem Sci 1996