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Vpu mediated degradation of CD4

Stable Identifier
R-HSA-180534
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
Summation

The HIV-1 Vpu protein promotes the degradation of the CD4 receptor by recruiting an SCF like ubiquitination complex that promotes CD4 degradation. Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4. The SKP1 component of the SCF complex is then recruited to the Vpu:beta-TrCP:CD4 promoting ubiquitination and subsequent proteasome-mediated degradation of CD4 (reviewed in Li et al., 2005). Vpu has also been shown to also increases progeny virus secretion from infected cells. Although the precise role of Vpu in this process is not yet known, it may affect ion conductive membrane pore formation and/or interference with TASK-1, an acid-sensitive K+ channel that inhibits virion release in some cells (see references in Li et al., 2005).

Literature References
PubMed ID Title Journal Year
16354571 Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions Cell Res 2005
15578980 Recent advances in the understanding of HIV-1 Vpu accessory protein functions Curr Drug Targets Immune Endocr Metabol Disord 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection