Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

Nuclear import of Rev protein

Stable Identifier
R-HSA-180746
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin beta-B23 complex associates with the nuclear pore through interactions between importin beta and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin beta resulting in in the disassembly of the importin beta-Rev-B23 complex and the release of Rev cargo.

Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms