Reactome: A Curated Pathway Database

Nuclear import of Rev protein

Stable Identifier
R-HSA-180746
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin beta-B23 complex associates with the nuclear pore through interactions between importin beta and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin beta resulting in in the disassembly of the importin beta-Rev-B23 complex and the release of Rev cargo.

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Disease
Diseases
Name Identifier Synonyms