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Nuclear import of Rev protein

Stable Identifier
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser

Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin beta-B23 complex associates with the nuclear pore through interactions between importin beta and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin beta resulting in in the disassembly of the importin beta-Rev-B23 complex and the release of Rev cargo.

Participant Of
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection