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RIP-mediated NFkB activation via ZBP1

Stable Identifier
R-HSA-1810476
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Overexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implicated in ZBP1-induced NFkB activation (Rebsamen M et al 2009; Kaiser WJ et al 2008).

Participants
Participant Of