Reactome: A Curated Pathway Database

RIP-mediated NFkB activation via ZBP1 (R-HSA-1810476) [Homo sapiens]


Overexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implicated in ZBP1-induced NFkB activation (Rebsamen M et al 2009; Kaiser WJ et al 2008).

Additional Information
Compartment cytosol
Cross References
Database Identifier
BioModels Database BIOMD0000000243, BIOMD0000000477, BIOMD0000000407