Reactome | Cytosolic sensors of pathogen-associated DNA

Cytosolic sensors of pathogen-associated DNA

Stable Identifier

R-HSA-1834949

DOI

10.3180/REACT_118823.3

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Cytosolic sensors of pathogen-associated DNA

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Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).

Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2.

Literature References

PubMed ID	Title	Journal	Year
23706668	Immune Sensing of DNA Bowie, AG, Paludan, SR	Immunity	2013
21533068	Innate immune sensing of DNA Fitzgerald, KA, Sharma, S	PLoS Pathog	2011
23706667	Cytosolic Sensing of Viruses Deddouche, S, Goubau, D, Reis e Sousa, C	Immunity	2013