Reactome: A Curated Pathway Database

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

Stable Identifier
R-HSA-1855174
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5(4) [cytosol] INPP5(4) [cytosol] inositol-1,4,5-trisphosphate 5-phosphatase activity (0052658)
Orthologous Events
Cross References
Rhea