Reactome | I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

Stable Identifier

R-HSA-1855174

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

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A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9430698	Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate Majerus, PW, Racusen, LC, Zhang, X, Philip, E, Hartz, PA	J Biol Chem	1998
7761412	The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Jefferson, AB, Auethavekiat, V, Majerus, PW, Zhang, X	Proc Natl Acad Sci U S A	1995
10593988	Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles Takenawa, T, Mochizuki, Y	J Biol Chem	1999
15474001	Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM	FEBS Lett	2004