I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (R-HSA-1855174) [Homo sapiens]


A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).

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Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
INPP5(4) inositol-1,4,5-trisphosphate 5-phosphatase activity (0052658)  
Cross References
Database Identifier
Rhea 19798, 19797, 19800
Literature References
pubMedId Title Journal Year
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation FEBS Lett 2004
10593988 Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles J Biol Chem 1999
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Proc Natl Acad Sci U S A 1995
9430698 Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate J Biol Chem 1998
Inferred Entries
Orthologous events