Reactome: A Curated Pathway Database

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (R-HSA-1855174)

Species Homo sapiens


A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).

The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
INPP5(4) inositol-1,4,5-trisphosphate 5-phosphatase activity (0052658)
Cross References
Database Identifier
Rhea 19798, 19797, 19800
Inferred Entries
Orthologous events