Reactome: A Curated Pathway Database

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (R-HSA-1855213)

Species Homo sapiens


Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

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Additional Information
Compartment plasma membrane , cytosol
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Cross References
Database Identifier
Rhea 11392, 11393, 11395
Inferred Entries
Orthologous events