Reactome: A Curated Pathway Database

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

Stable Identifier
R-HSA-1855213
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of Inositol polyphosphate 5-phosphatase [plasma membrane] Inositol polyphosphate 5-phosphatase [plasma membrane] inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (0052659)
Orthologous Events
Cross References
Rhea