Reactome: A Curated Pathway Database

Extension of pseudopodia by myosin-X in a PI3K dependent manner (R-HSA-1861595)

Species Homo sapiens

Summation

Myosin-X (Myosin 10) is one of the downstream effectors of PI3K in FCGR-phagocytosis and is involved in pseudopod extension and closure of phagocytic cups. It is recruited to the forming phagosome by binding, through its second PH domain to membrane PIP3, a major product of PI3-kinase (Cox et al. 2002). Myosin-X may act as a motor to transport membrane cargo molecules to the forming pseudopods, influencing actin dynamics. It is not understood with certainty how myosin X contributes to the mechanism of pseudopod extension. It selectively binds to actin bundle such that each head may bind, in an ATP-sensitive manner, to two adjacent actin filaments within the actin bundle. Myosin X hydrolyze ATP and converts this chemical energy to mechanical energy moving toward the plus end/barbed end of the actin filament facing towards the tip of the growing pseudopods (Araki 2006, Chavrier 2003, Watanabe et al 2010).

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol
Catalyst Activity
PhysicalEntity Activity Active Units
Myosin-X dimer motor activity (0003774)
Literature References
pubMedId Title Journal Year
12055636 Myosin X is a downstream effector of PI(3)K during phagocytosis Nat Cell Biol 2002
12105426 May the force be with you: Myosin-X in phagocytosis Nat Cell Biol 2002