Reactome: A Curated Pathway Database

Downstream signal transduction (R-HSA-186763)

Species Homo sapiens

Summation

The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.
Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
10508235 Mechanism of action and in vivo role of platelet-derived growth factor Physiol Rev 1999
9739761 Signal transduction via platelet-derived growth factor receptors Biochim Biophys Acta 1998