Reactome: A Curated Pathway Database

Signaling by PDGF (R-HSA-186797) [Homo sapiens]


Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell.

Literature References
pubMedId Title Journal Year
10508235 Mechanism of action and in vivo role of platelet-derived growth factor Physiol Rev 1999
9739761 Signal transduction via platelet-derived growth factor receptors Biochim Biophys Acta 1998
15207811 The PDGF family: four gene products form five dimeric isoforms Cytokine Growth Factor Rev 2004