Reactome: A Curated Pathway Database

NGF signalling via TRKA from the plasma membrane (R-HSA-187037)

Species Homo sapiens

Summation

Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the likely outcome of short term signalling, as observed following stimulation of EGFR (EGF receptor). Long term signalling via TRK receptors, instead, was clearly shown to be required for neuronal differentiation in response to neurotrophins.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
11520933 Nerve growth factor signaling, neuroprotection, and neural repair Annu Rev Neurosci 2001
12676795 Trk receptors: roles in neuronal signal transduction Annu Rev Biochem 2003
10579918 Neurotrophin signaling via Trks and p75 Exp Cell Res 1999
10851172 Neurotrophin signal transduction in the nervous system Curr Opin Neurobiol 2000