Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible.
|GO Biological Process||neurotrophin TRK receptor signaling pathway (0048011)|
|1315923||The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins||Mol Cell Biochem||1992|
|1844238||The trk family of oncogenes and neurotrophin receptors||Princess Takamatsu Symp||1991|