Reactome: A Curated Pathway Database
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TRKA activation by NGF

Stable Identifier
R-HSA-187042
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible.

Literature References
Participants
Participant Of
Orthologous Events