Reactome: A Curated Pathway Database

TRKA activation by NGF (R-HSA-187042)

Species Homo sapiens


Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible.

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Additional Information
GO Biological Process neurotrophin TRK receptor signaling pathway (0048011)