Signalling to ERKs

Stable Identifier
R-HSA-187687
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signalling to ERKs
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Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours.
Literature References
PubMed ID Title Journal Year
10508738 Extracellular-signal-regulated kinase signalling in neurons

Stork, PJ, Grewal, SS, York, RD

Curr Opin Neurobiol 1999
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Orthologous Events
Signalling to ERKs (Bos taurus)
Signalling to ERKs (Caenorhabditis elegans)
Signalling to ERKs (Canis familiaris)
Signalling to ERKs (Danio rerio)
Signalling to ERKs (Dictyostelium discoideum)
Signalling to ERKs (Drosophila melanogaster)
Signalling to ERKs (Gallus gallus)
Signalling to ERKs (Mus musculus)
Signalling to ERKs (Plasmodium falciparum)
Signalling to ERKs (Rattus norvegicus)
Signalling to ERKs (Saccharomyces cerevisiae)
Signalling to ERKs (Schizosaccharomyces pombe)
Signalling to ERKs (Sus scrofa)
Signalling to ERKs (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-09-21)
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