Reactome: A Curated Pathway Database

Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)

Stable Identifier
R-HSA-188467
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

FAD-linked mitochondrial glycerol 3-phosphate dehydrogenase (GPD2, alias: mGPDH) and its NAD-linked cytosolic isoform (GPD1, alias:cGPDH) constitute glycerol phosphate shuttle. GPD2 catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Impaired activity of GPD2 has been suggested to be one of the primary causes of insulin secretory defects in beta-cells and thus it is a candidate gene for type 2 diabetes.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
glycerol-3-phosphate dehydrogenase activity of GPD2 [mitochondrial inner membrane] GPD2 [mitochondrial inner membrane] glycerol-3-phosphate dehydrogenase activity (0004368)
Orthologous Events
Cross References
Rhea