FAD-linked mitochondrial glycerol 3-phosphate dehydrogenase (GPD2, alias: mGPDH) and its NAD-linked cytosolic isoform (GPD1, alias:cGPDH) constitute glycerol phosphate shuttle. GPD2 catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Impaired activity of GPD2 has been suggested to be one of the primary causes of insulin secretory defects in beta-cells and thus it is a candidate gene for type 2 diabetes.
|GPD2||glycerol-3-phosphate dehydrogenase activity (0004368)|
|Biochemistry, 4th ed||1995|
|7821823||The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA||Gene||1994|
|8687421||Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene||Biochem Biophys Res Commun||1996|
|8163052||Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients||Diabetologia||1994|