Reactome: A Curated Pathway Database

FGFR2b binds to FGF

Stable Identifier
R-HSA-190260
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In this reaction, FGF receptor 2b in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets.

Literature References
Participants
Participant Of
This entity is regulated by:
Orthologous Events