Reactome: A Curated Pathway Database

FGFR2b binds to FGF (R-HSA-190260) [Homo sapiens]

Black Box Event

In this reaction, FGF receptor 2b in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets.

Additional Information
Compartment plasma membrane
This entry is regulated by
Regulation type Name